Laboratory of Physiology of Digestion

phone/fax: (813) 70 72 738; (812) 976 30 93 aia.335      e-mail: digestion-lab@kolt.infran.ru

Applied research

  1. Contract "Study of antiproliferative potency of test substance XXX in a rat model of laser induced choroidal neovascularization" Contract № NCL/2012/Mab/R, March 13, 2012 with Pharm-Holding Ltd., Russia. Principal investigator - Lentsman M.
  2. Contract "Study of chronic toxicity of the substance XXXXX  after a single daily, within one month of intravenous and intramuscular administration in rabbits (male and female)." Planned. Principal investigator - Lentsman M.
  3.  Collaborative research agreement  with the Institute for Innovations,  Ajinomoto Co., Inc.February 18, 2011: "Influence of taste on the stomach. The interaction between amino acids in control of cephalic and intestinal phases of gastric secretion (2011-2012). Principal investigator - Zolotarev V .
  4.  Contract "Assessment of the test substance XXXXX in  the humoral immune response in a model of " the determination of antibody-forming cells". Planned. Principal investigator - Lentsman M.
  5. Contract  "Comparative study of the effect of Cortexin on neurological, behavioral, morphological parameters and mortality in the rat model of experimental stroke (permanent middle cerebral artery occlusion) after the intramuscular and intravenous administration of test substance." Contract № COR/070309/3 , April 12, 2010 with Geropharm Ltd. Completed. Principal investigator - Lentsman M.
  6.  Collaborative research agreement  with the Institute for Innovations,  Ajinomoto Co., Inc. March 2, 2010 "The mechanism of action of monosodium glutamate on gastric secretion." Principal investigator - Zolotarev V.
  7. Contract "Evaluation of the of anti-inflammatory (anti-edema) activity of the test articles Prostamaks, Kortagen, Vilon and Cortexin in a model of carrageenan paw edema in rats." Contract No CAR/180909/1,  22.09.2009 with Company Geropharm Ltd.. Completed. Principal investigator - Lentsman M.
  8. Collaborative research agreement with the Institute for Innovations,  Ajinomoto Co., Inc on February 1, 2009. "Enhancement by  monosodium glutamate of gastric secretion." Principal investigator - Zolotarev V.
  9.  Contract "Investigation of the influence of the test article Vezilut on the contractile activity of  urinary bladder in intact rats and rats with a model of acute cystitis." Contract № 01/08, 12.05.2008 with  Excess Bioscience Ltd. Principal investigator - Lentsman M.
  10. Collaborative research agreement  with the Institute for Innovations,  Ajinomoto Co., Inc.  November 10, 2006. "The interaction of umami substances with the major groups of nutrients during the regulation of gastric phase of gastric secretion."Principal investigator - Zolotarev V.
  11. Collaborative research agreement  with the Institute for Innovations,  Ajinomoto Co., Inc. November 5, 2005 "The physiological significance of monosodium glutamate in the digestion of protein." Principal investigator - Zolotarev V.
  12. Contract with «Trans-Technology" concern "Alkor Bio" (Russia): "Investigation of  efficiency of exogenous mesenchymal stem cells in compensation of neurological, behavioral and morphological disturbances after ischemic stroke in rats with long-term (6 weeks) neurologic and behavioral testing of animals", 2003 -2004. Principal investigator - Lentsman M.
  13.  Contract  15P-01-03-SD with ASGL-Research Laboratories Ltd. "Evaluation of anti-arrhythmic and cardioprotective action of the preparation CG-05 in acute experimental myocardial ischemia and reperfusion in anesthetized rats,"  2000. Principal investigator -  Zolotarev V., Study Director - Lentsman M.
  14.  Contract  NIR-0005-6/14-06-2001 with  ASGL-Research Laboratories Ltd. "Evaluation of cardioprotective action of CG-05 in small doses in rats with occlusion of the descending branch of left coronary artery," 2001. Principal investigator -  Zolotarev V., Study Director - Lentsman M.
  15. Contract  with the Novosibirsk Institute of Organic Chemistry SB RAS (head works of the SB RAS Prof. E.E.Shults) "The effect  of a new antiulcer drug Bisulfana on  secretion of acid, bicarbonate and pepsinogen in the stomach of rats. "March 24, 2000 Principal investigator - Zolotarev V.
  16. Contract number 3/SNT-99,  June 7, 1999with ASGL Research Laboratories Ltd. "The role of corticotropin-releasing hormone in the control of cognitive and visceral functions." Principal investigator - Polenov S.
  17.  Contract № 56-99, June 7, 1999  with ASGL Research Laboratories Ltd. "Assessement the influence of substances on gastric secretion  in anesthetized rats." Principal investigator - Zolotarev V.
  18.  Contract with Neurobiological Technologies, Inc, (USA): «Effect of substance UCW 4938 on the development of experimental tumors (Walker and Ehrlich carcinoma) in rats, 1999. Principal investigator - Lentsman M.
  19. Contract with Neurobiological Technologies, Inc, (USA): «The influence of the investigated compounds X1, X2 and X3 on the electrical stimulation-induced contractile activity of isolated smooth muscle preparation of the small intestine of guinea pigs and phreniko-diaphragmatic preparation of rats." 2000 PI -  Zolotarev V.
  20.  Contract with the Department of Pharmacology and Toxicology, University of California, Berkeley, USA. "The influence of analogs of corticotropin-releasing hormone on the healing of incisional skin wounds in rats." 1999-2000. Principal investigator - Lentsman M.
  21.  Contract with JASGL-Research Laboratories Ltd. "Studies of the effect of substance ANG-1 on  dynamics of healing of full-cut lesions of the skin of rats," 1999. PI Lentsman M.
  22. Contract with the Department of Pharmacology and Toxicology, University of California, Berkeley, USA. «Studies on hypotensive properties of D-Glu20-hCRF, Mystixin-7 and their interaction with Substance P." 1996-1997. Principal investigator - Lentsman M.
  23. Contract with the Department of Pharmacology and Toxicology, University of California, Berkeley, USA. "Studying the impact of new analogues corticotropin-releasing hormone on the system parameters (blood pressure, ECG and respiration) in anesthetized rats," 1998. Principal investigator - Lentsman M.
  24. Contract with the Department of Pharmacology and Toxicology, University of California,  Berkeley, USA: «The effects of different doses of native h / rCRF & D-Glu20-h/rCRF on MAP, Heart Rate, & Respiration Rate & hypotensive potency of Substance P in Nembutal anaesthetized male SD rats », 1997. PI Lentsman M.
  25. Contract HM9239/40/46/-B/P-94-Ca-001/Atr1  Russian-American joint venture  "Neofarm." "The influence of substances HM9239, 9240, 9246 on the contractile activity of the left atrium of the guinea pig." 1996. Principal investigator - Zolotarev V.

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